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. downloadPathophysiology and treatment of aortic occlusive disease.
Aortic occlusive disease is frequently encountered in clinical practice and can be divided into three subtypes. Subcritical stenosis or subcritical occlusion is defined as a stenosis that does not exceed the physiological high-flow wave-speed pressure gradient. The clinical implication of subcritical stenosis is vasodilatation at rest and abnormal changes of blood pressure during exercise. Subcritical stenosis is usually caused by aging, hypertension, diabetes mellitus, and hyperlipidemia. It is characterized by endothelial dysfunction, with functional changes in the tunica intima and media. The clinical implications of subcritical stenosis are relatively mild, such as hypertension, dyslipidemia, and congestive heart failure. Subcritical occlusion is defined as an obstruction that does not exceed the physiological high-flow wave-speed pressure gradient. Subcritical occlusion is always associated with aortic stenosis. Subcritical stenosis and subcritical occlusion are usually associated with intensive atherosclerosis in the presence of normal hemodynamics and normal flow. The clinical implication of subcritical stenosis is systolic hypertension and diastolic hypotension during exercise. The clinical implication of subcritical occlusion is hypertension. The prognosis of subcritical stenosis is relatively good. Subcritical stenosis can be treated with aggressive control of risk factors, such as blood pressure, dyslipidemia, and diabetes mellitus. The prognosis of subcritical stenosis is good, even with conservative treatment. Subcritical occlusion is also treated with aggressive control of risk factors, particularly hypertension. Angioplasty or surgical revascularization is recommended in subcritical stenosis when blood pressure cannot be well controlled.Gift Guide: Dressing up for your baby
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Gift Guide: Dressing up for your baby
Elegant and sophisticated. These are two words that never go together for most of us when it comes to baby dresses. Here, designer Clare Waight Keller tells us how to dress up for your little one with these easy-to-make outfits.Q:
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